نوع مقاله : مقاله کامل پژوهشی

نویسندگان

1 دانشجوی دکتری، گروه علوم و صنایع غذایی، واحد قوچان، دانشگاه آزاد اسلامی، قوچان، ایران

2 استادیار، گروه علوم و صنایع غذایی، واحد قوچان، دانشگاه آزاد اسلامی، قوچان، ایران

3 استاد، گروه نانوفناوری مواد غذایی، مؤسسه پژوهشی علوم و صنایع غذایی، مشهد، ایران

4 دانشیار، گروه شیمی مواد غذایی، مؤسسه پژوهشی علوم و صنایع غذایی، مشهد، ایران

چکیده

باتوجه‌به ارزش بالای تغذیه‌ای ویتامین D3 و ازطرفی ناپایداری آن در شرایط مختلف محیطی و فراوری، لزوم حفظ آن ازطریق تکنیک‌هایی مانند ریزپوشانی طی مغذی‌کردن مواد خوراکی با آن حس می‌شود. در این مطالعه ویتامین D3 در ساختار نیوزوم‌های بر پایۀ سورفاکتانت‌های مختلف (اسپن 60، توئین 20 و 80) و کلسترول با نسبت‌های (80:20 و 60:40 وزنی/وزنی) با استفاده از روش هیدراسیون لایۀ نازک-سونیکاسیون انکپسوله شد. مشخص گردید که نیوزوم‌های تهیه‌شده با توئین 20 و 80 با نسبت سورفاکتانت به کلسترول (80:20 وزنی/وزنی) از کمترین میانگین اندازۀ ذرات، کمترین شاخص پراکندگی و بیشترین مقدار پتانسیل زتا برخوردار بودند. همچنین این نمونه‌ها از کارایی انکپسولاسیون بالا و اندازه‌ای در حدود مقیاس نانو بودند. تعیین پایداری ویتامین D3 طی 1 ماه نگهداری در دمای یخچال برای نمونه‌های نانونیوزوم بر پایۀ توئین 20 و 80 با نسبت سورفاکتانت به کلسترول (80:20 وزنی/وزنی) صورت گرفت. نتایج نشان داد که نانونیوزوم‌های بر پایۀ توئین 20 پایداری بیشتری نسبت به نمونه‌های بر پایۀ توئین 80 طی 1 ماه نگهداری داشتند. همچنین قابلیت زیست‌دسترسی ویتامین D3 پس از هضم کامل تحت‌شرایط شبیه‌سازی‌شدۀ دستگاه گوارش موردارزیابی قرار گرفت. براین‌اساس مشخص شد که قابلیت زیست‌دسترسی ویتامین D3 در حالت آزاد 58 درصد می‌باشد که طراحی نانونیوزوم‌های بر پایۀ توئین قابلیت زیست‌دسترسی آن را به‌طور معنی‌داری (0/05>P) بهبود بخشید. به‌طوری‌که بیشترین قابلیت زیست‌دسترسی ویتامین D3 برای نانونیوزوم‌های توئین 20 با نسبت سورفاکتانت به کلسترول (80:20 وزنی/وزنی) حاصل گردید.

کلیدواژه‌ها

Abdelkader, H., Farghaly, U., & Moharram, H. (2014). Effects of surfactant type and cholesterol level on niosomes physical properties and in vivo ocular performance using timolol maleate as a model drug. Journal of pharmaceutical investigation, 44(5), 329-337. doi:https://doi.org/10.1007/s40005-014-0121-8
Akbari, J., Saeedi, M., Enayatifard, R., Morteza-Semnani, K., Hashemi, S. M. H., Babaei, A., . . . Nokhodchi, A. (2020). Curcumin Niosomes (curcusomes) as an alternative to conventional vehicles: A potential for efficient dermal delivery. Journal of Drug Delivery Science and Technology, 60, 102035. doi:https://doi.org/10.1016/j.jddst.2020.102035
Akbarzadeh, I., Yaraki, M. T., Ahmadi, S., Chiani, M., & Nourouzian, D. (2020). Folic acid-functionalized niosomal nanoparticles for selective dual-drug delivery into breast cancer cells: An in-vitro investigation. Advanced Powder Technology, 31(9), 4064-4071. doi:https://doi.org/10.1016/j.apt.2020.08.011
Basiri, L., Rajabzadeh, G., & Bostan, A. (2017). α-Tocopherol-loaded niosome prepared by heating method and its release behavior. Food chemistry, 221, 620-628. doi:https://doi.org/10.1016/j.foodchem.2016.11.129
Bayindir, Z. S., & Yuksel, N. (2010). Characterization of niosomes prepared with various nonionic surfactants for paclitaxel oral delivery. Journal of pharmaceutical sciences, 99(4), 2049-2060. doi:https://doi.org/10.1002/jps.21944
Brandão-Lima, P. N., Santos, B. d. C., Aguilera, C. M., Freire, A. R. S., Martins-Filho, P. R. S., & Pires, L. V. (2019). Vitamin D food fortification and nutritional status in children: A systematic review of randomized controlled trials. Nutrients, 11(11), 2766. doi:https://doi.org/10.3390/nu11112766
Cano-Sarmiento, C., Téllez-Medina, D., Viveros-Contreras, R., Cornejo-Mazón, M., Figueroa-Hernández, C., García-Armenta, E., . . . Gutiérrez-López, G. (2018). Zeta potential of food matrices. Food Engineering Reviews, 10(3), 113-138. doi:https://doi.org/10.1007/s12393-018-9176-z
Chanda, H., Das, P., Chakraborty, R., & Ghosh, A. (2011). Development and evaluation of liposomes of fluconazole. J Pharm Biomed Sci, 5(27), 1-9.
Charpashlo, E., Ghorani, B., & Mohebbi, M. (2021). Multilayered electrospinning strategy for increasing the bioaccessibility of lycopene in gelatin-based sub-micron fiber structures. Food hydrocolloids, 113, 106411. doi:https://doi.org/10.1016/j.foodhyd.2020.106411
Eid, R. K., Essa, E. A., & El Maghraby, G. M. (2019). Essential oils in niosomes for enhanced transdermal delivery of felodipine. Pharmaceutical development and technology, 24(2), 157-165. doi:https://doi.org/10.1080/10837450.2018.1441302
El-Samaligy, M., Afifi, N., & Mahmoud, E. (2006). Increasing bioavailability of silymarin using a buccal liposomal delivery system: preparation and experimental design investigation. International journal of pharmaceutics, 308(1-2), 140-148. doi:https://doi.org/10.1016/j.ijpharm.2005.11.006
Essa, E. A. (2014). Effect of formulation and processing variables on the particle size of sorbitan monopalmitate niosomes. Asian Journal of Pharmaceutics (AJP): Free full text articles from Asian J Pharm, 4(4). doi:http://dx.doi.org/10.22377/ajp.v4i4.289
Estupiñán Sánchez, Ó. R., García Manrique, P., Blanco López, M. d. C., Matos González, M., & Gutiérrez Cervelló, G. (2020). Vitamin D3 loaded niosomes and transfersomes produced by ethanol injection method: identification of the critical preparation step for size control. Foods, 9(10), 1367. doi:https://doi.org/10.3390/foods9101367
Etcheverry, P., Grusak, M. A., & Fleige, L. E. (2012). Application of in vitro bioaccessibility and bioavailability methods for calcium, carotenoids, folate, iron, magnesium, polyphenols, zinc, and vitamins B6, B12, D, and E. Frontiers in physiology, 3, 317. doi:https://doi.org/10.3389/fphys.2012.00317
Gharbavi, M., Johari, B., Mousazadeh, N., Rahimi, B., Leilan, M. P., Eslami, S. S., & Sharafi, A. (2020). Hybrid of niosomes and bio-synthesized selenium nanoparticles as a novel approach in drug delivery for cancer treatment. Molecular Biology Reports, 47(9), 6517-6529. doi:https://doi.org/10.1007/s11033-020-05704-z
Goyal, H., Perisetti, A., Rahman, M. R., Levin, A., & Lippi, G. (2019). Vitamin D and gastrointestinal cancers: a narrative review. Digestive diseases and sciences, 64(5), 1098-1109. doi:https://doi.org/10.1007/s10620-018-5400-1
Gutiérrez, G., Matos, M., Barrero, P., Pando, D., Iglesias, O., & Pazos, C. (2016). Iron-entrapped niosomes and their potential application for yogurt fortification. LWT, 74, 550-556. doi:https://doi.org/10.1016/j.lwt.2016.08.025
Hasan, A. A. (2014). Design and in vitro characterization of small unilamellar niosomes as ophthalmic carrier of dorzolamide hydrochloride. Pharmaceutical development and technology, 19(6), 748-754. doi:https://doi.org/10.3109/10837450.2013.829095
Holick, M. F. (2004). Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. The American journal of clinical nutrition, 80(6), 1678S-1688S. doi:https://doi.org/10.1093/ajcn/80.6.1678S
Holick, M. F. (2007). Vitamin D deficiency. New England journal of medicine, 357(3), 266-281. doi:https://doi.org/10.1056/NEJMra070553
Jafari, S. M., Assadpoor, E., He, Y., & Bhandari, B. (2008). Re-coalescence of emulsion droplets during high-energy emulsification. Food hydrocolloids, 22(7), 1191-1202. doi:https://doi.org/10.1016/j.foodhyd.2007.09.006
Junyaprasert, V. B., Singhsa, P., Suksiriworapong, J., & Chantasart, D. (2012). Physicochemical properties and skin permeation of Span 60/Tween 60 niosomes of ellagic acid. International journal of pharmaceutics, 423(2), 303-311. doi:https://doi.org/10.1016/j.ijpharm.2011.11.032
Khan, W. A., Butt, M. S., Pasha, I., & Jamil, A. (2020). Microencapsulation of vitamin D in protein matrices: In vitro release and storage stability. Journal of Food Measurement and Characterization, 14(3), 1172-1182. doi:https://doi.org/10.1007/s11694-019-00366-3
Khatoon, M., Shah, K. U., Din, F. U., Shah, S. U., Rehman, A. U., Dilawar, N., & Khan, A. N. (2017). Proniosomes derived niosomes: recent advancements in drug delivery and targeting. Drug delivery, 24(2), 56-69. doi:https://doi.org/10.1080/10717544.2017.1384520
Khoee, S., & Yaghoobian, M. (2017). Chapter 6 - Niosomes: a novel approach in modern drug delivery systems. In E. Andronescu & A. M. Grumezescu (Eds.), Nanostructures for Drug Delivery (pp. 207-237): Elsevier.
Lin, Y., Wang, Y.-H., Yang, X.-Q., Guo, J., & Wang, J.-M. (2016). Corn protein hydrolysate as a novel nano-vehicle: Enhanced physicochemical stability and in vitro bioaccessibility of vitamin D3. LWT-Food Science and Technology, 72, 510-517. doi:https://doi.org/10.1016/j.lwt.2016.05.020
Lindfors, L., Skantze, P., Skantze, U., Westergren, J., & Olsson, U. (2007). Amorphous drug nanosuspensions. 3. Particle dissolution and crystal growth. Langmuir, 23(19), 9866-9874. doi:https://doi.org/10.1021/la700811b
Lu, Q., Li, D.-C., & Jiang, J.-G. (2011). Preparation of a tea polyphenol nanoliposome system and its physicochemical properties. Journal of agricultural and food chemistry, 59(24), 13004-13011. doi:https://doi.org/10.1021/jf203194w
Moghassemi, S., & Hadjizadeh, A. (2014). Nano-niosomes as nanoscale drug delivery systems: an illustrated review. Journal of controlled release, 185, 22-36. doi:https://doi.org/10.1016/j.jconrel.2014.04.015
Moghddam, S. R. M., Ahad, A., Aqil, M., Imam, S. S., & Sultana, Y. (2016). Formulation and optimization of niosomes for topical diacerein delivery using 3-factor, 3-level Box-Behnken design for the management of psoriasis. Materials Science and Engineering: C, 69, 789-797. doi:https://doi.org/10.1016/j.msec.2016.07.043
Mohammadi, A., Jafari, S. M., Mahoonak, A. S., & Ghorbani, M. (2021). Liposomal/nanoliposomal encapsulation of food-relevant enzymes and their application in the food industry. Food and Bioprocess Technology, 14(1), 23-38. doi:https://doi.org/10.1007/s11947-020-02513-x
Mohammadi, M., Ghanbarzadeh, B., & Hamishehkar, H. (2014). Formulation of nanoliposomal vitamin D3 for potential application in beverage fortification. Advanced pharmaceutical bulletin, 4(Suppl 2), 569-575. doi:https://doi.org/10.5681/apb.2014.084
Mura, S., Pirot, F., Manconi, M., Falson, F., & Fadda, A. M. (2007). Liposomes and niosomes as potential carriers for dermal delivery of minoxidil. Journal of Drug Targeting, 15(2), 101-108. doi:https://doi.org/10.1080/10611860600991993
Nasseri, B. (2005). Effect of cholesterol and temperature on the elastic properties of niosomal membranes. International journal of pharmaceutics, 300(1-2), 95-101. doi:https://doi.org/10.1016/j.ijpharm.2005.05.009
Pardakhty, A., Varshosaz, J., & Rouholamini, A. (2007). In vitro study of polyoxyethylene alkyl ether niosomes for delivery of insulin. International journal of pharmaceutics, 328(2), 130-141. doi:https://doi.org/10.1016/j.ijpharm.2006.08.002
Porter, C. J., Trevaskis, N. L., & Charman, W. N. (2007). Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs. Nature reviews Drug discovery, 6(3), 231-248. doi:https://doi.org/10.1038/nrd2197
Talebi, V., Ghanbarzadeh, B., Hamishehkar, H., Pezeshki, A., & Ostadrahimi, A. (2021). Effects of different stabilizers on colloidal properties and encapsulation efficiency of vitamin D3 loaded nano-niosomes. Journal of Drug Delivery Science and Technology, 61, 101284. doi:https://doi.org/10.1016/j.jddst.2019.101284
Valer-Martinez, A., Martinez, J. A., Sayon-Orea, C., Galvano, F., Grosso, G., & Bes-Rastrollo, M. (2019). Vitamin D and Cardio-Metabolic Risk Factors in Overweight Adults: An Overview of the Evidence. Current pharmaceutical design, 25(22), 2407-2420. doi:https://doi.org/10.2174/1381612825666190722103919
Waddad, A. Y., Abbad, S., Yu, F., Munyendo, W. L., Wang, J., Lv, H., & Zhou, J. (2013). Formulation, characterization and pharmacokinetics of Morin hydrate niosomes prepared from various non-ionic surfactants. International journal of pharmaceutics, 456(2), 446-458. doi:https://doi.org/10.1016/j.ijpharm.2013.08.040
Wagh, V. D., & Deshmukh, O. J. (2012). Itraconazole niosomes drug delivery system and its antimycotic activity against Candida albicans. International Scholarly Research Notices, 2012. doi:https://doi.org/10.5402/2012/653465
Wagner, M. E., Spoth, K. A., Kourkoutis, L. F., & Rizvi, S. S. (2016). Stability of niosomes with encapsulated vitamin D3 and ferrous sulfate generated using a novel supercritical carbon dioxide method. Journal of liposome research, 26(4), 261-268. doi:https://doi.org/10.3109/08982104.2015.1088868
Winuprasith, T., Khomein, P., Mitbumrung, W., Suphantharika, M., Nitithamyong, A., & McClements, D. J. (2018). Encapsulation of vitamin D3 in pickering emulsions stabilized by nanofibrillated mangosteen cellulose: Impact on in vitro digestion and bioaccessibility. Food hydrocolloids, 83, 153-164. doi:https://doi.org/10.1016/j.foodhyd.2018.04.047
Xiong, W., Ren, C., Li, J., & Li, B. (2018). Enhancing the photostability and bioaccessibility of resveratrol using ovalbumin–carboxymethylcellulose nanocomplexes and nanoparticles. Food & function, 9(7), 3788-3797. doi:https://doi.org/10.1039/C8FO00300A